Can Gio Biosphere Reserve is located in Can Gio district (previously Duyen Hai district), in the coastal zone of Ho Chi Minh City. The area is situated in a recently formed estuary complex of tidal flats, where the Vam Co, Saigon and Dong Nai rivers discharge into the sea. The topography of Can Gio is low-lying and dynamic. The site is divided by a network of canals and rivers.